Pandemic Action Network Statement on the Second Global COVID-19 Summit

The Second Global COVID-19 Summit showed a renewed commitment to end the COVID-19 crisis and prevent the next pandemic threat. Against complacency and pandemic fatigue, leaders from over 35 countries, the private sector, philanthropy, and civil society brought forward new actions and commitments — both financial and non-financial — to meet urgent needs across the summit’s priorities of vaccinating the world, protecting the most vulnerable, and preventing future pandemics. Financial commitments totaled almost US$3.2 billion, with approximately US$2.5 billion in funding from governments, and approximately US$700 million from the private sector, foundations, and other non-government actors.

Statement from Carolyn Reynolds, Co-Founder, Pandemic Action Network

Today’s Global COVID-19 Summit was a win against complacency and has provided a much-needed shot in the arm for both the global COVID response and to begin to prepare the world for the next pandemic threat. We are pleased that the Summit has yielded important new commitments to vaccinate the world, save lives, and nearly US$1 billion to establish a new Fund for global health security and pandemic preparedness. This is a significant down payment and enables the World Bank to move forward on establishing the Fund this summer. But we must maintain the momentum beyond today and political leaders must stay in the fight. This pandemic is not over, and the world must move faster to deliver lifesaving tools and prepare for whatever variant or pandemic threat is coming next. The U.S. Congress must urgently approve additional funding for the global COVID response, and other governments and private and philanthropic partners must step up support for the response and for the Fund as soon as possible.

Statement from Eloise Todd, Co-Founder, Pandemic Action Network

World leaders‘ commitments at the Global COVID-19 Summit today have helped give a much-needed reset to the global COVID response. But without sustained and decisive action, the world could slip into permanent inequity between those that are able to be treated and vaccinated for COVID-19 and those that are not. All eyes are on global and regional bodies to see how they can build on today’s starting shot and deliver real progress by the G7 Summit at the end of June.

As long championed by Pandemic Action Network, equity featured prominently in both reflections on the COVID-19 pandemic and in new commitments. We welcome commitments and new investments to close the funding gap for the Access to COVID-19 Tools Accelerator (ACT-A), solve for last-mile vaccination delivery challenges, accelerate access to generic therapeutics, and diversify manufacturing and procurement of medical countermeasures to build strong and sustainable systems in every region of the world.

Pandemic Action Network was also pleased to see political and financial support for a new Fund for Global Health Security and Pandemic Preparedness from across sectors. As we double down to end the COVID-19 pandemic, we also must look ahead and prepare both for future COVID-19 variants and emerging disease threats. Government leaders from around the world stepped up today to support a new pandemic preparedness fund and advocated for the need to include diverse voices in the design and governance of a new fund. Financial commitments from the U.S., European Commission, Germany, and the Wellcome Trust total nearly US$1 billion, and represent a significant down payment toward the US$10 billion needed annually for this Fund.

But while today’s Summit serves as a needed jolt to the global COVID-19 effort, there is still much work to do. Today’s financial commitments for response sum just over US$2 billion, and while this funding is urgently needed, it’s long overdue and far short of the current ACT-A funding gap (nearly $US15 billion). It is critical that all governments and sectors step up and prioritize significant new resources to end the global COVID crisis — including the U.S. Congress and Administration working together to transcend politics and quickly pass at least US$5 billion for the global COVID-19 response. In addition, it is critical to heed the call from many African leaders for Gavi, the Global Fund, and other vaccine purchasers to prioritize purchases from African vaccine manufacturers to ensure new facilities are sustainable. It will also be important for a diversity of donors and stakeholders to commit to the new Fund for Global Health Security and Pandemic Preparedness to ensure it is inclusive, representative, and effective. 

As we look ahead to the World Health Assembly, G7 and G20 Summits, and UN General Assembly, Pandemic Action Network will stay vigilant to make sure Summit commitments are realized and accountable, and that world leaders are collectively challenging themselves to do whatever it takes to end this crisis for everyone, everywhere.

Steps Taken, a Leap Required — CEPI’s Replenishment Statement

Today, as the world reaches a grim milestone of six million official deaths from the COVID-19 pandemic and as Russia wages war in Ukraine, world leaders gathered at the Global Pandemic Preparedness Summit to address what we must do better to prevent and prepare for pandemic threats. The Summit, organized by the Coalition for Epidemic Preparedness Innovations (CEPI) and the U.K. Government, represented a critical opportunity for global leaders to prioritize pandemic preparedness and support CEPI’s groundbreaking 5-year plan to develop life-saving vaccines to help prevent a crisis of similar scale to the COVID-19 pandemic, including its 100 Days Mission to develop safe and effective vaccines in 100 days following an outbreak. 

Pledges of financial and political support were made in nearly equal measure with a total of 13 countries and 2 philanthropic donors pledging US$1.54 billion to CEPI’s US$3.5 billion five-year plan. Japan’s announcement of US$300 million made it the largest contributor, followed by the U.K. in addition to commitments from Australia, Austria, Finland, Germany, Indonesia, Italy, Japan, Mexico, New Zealand, Norway, Singapore, and the U.S. 

At least nine other countries (Brazil, Canada, Greece, Kuwait, Lithuania, Nigeria, South Korea, Spain, and Switzerland) and the European Commission expressed their support, though no specific financial contribution was mentioned. 

While this is a welcome and important first step toward a world that is better prepared for pandemic threats, it is disappointing that many governments failed to match political support with bold and meaningful financial commitments. The COVID-19 pandemic showed us that the world is ill-prepared to prevent and respond to a pandemic caused by a novel respiratory pathogen. The pandemic research and development (R&D) system as it exists does not work to address the challenges of emerging infectious diseases. As we look toward year three of COVID, we are already witnessing the familiar and costly cycle of panic and neglect around pandemics spinning into motion. CEPI’s plan to reduce vaccine development time to 100 days is one in a set of critical measures to get ahead of the cycle of panic and neglect and avoid another trillion-dollar pandemic that needlessly costs millions of lives and livelihoods. 

Eloise Todd, Pandemic Action Network’s co-founder, said:

“While today’s commitments of over US$1.5 billion to CEPI are a welcome and strong start, they are not enough. The COVID crisis showed us that the vaccine R&D system as it exists cannot meet the challenges of emerging infectious diseases before they cause severe damage, nor can it ensure all people everywhere have equitable access to the tools and technologies they need to curb a global health emergency. Leaders can avoid repeating past mistakes and build a system that is forward looking and equitable. Fully funding CEPI is an impactful way to do just that. An investment in CEPI is a fraction of the trillions lost to pandemic response and an investment that pays a multitude of dividends. We expect key global leaders to step up in the coming weeks to align their financial commitments with their political commitments, and make a fully-funded CEPI a reality.”

Pandemic Action Network and its network of over 250 partners will follow up closely on the actions of governments, philanthropies, and decision makers who have expressed their commitment to this goal, especially those key global leaders who can convene other governments, rally support, and mobilize resources. Building on the strong momentum from the Global Pandemic Preparedness Summit, concerted action from world leaders in the coming months will be crucial to fully fund CEPI and ensuring the COVID crisis leaves a legacy of pandemic preparedness.

CEPI’s Unique Impact Opportunity: Pandemic Preparedness & Response R&D

The Coalition for Epidemic Preparedness Innovations (CEPI) was founded with the mission to accelerate the development of vaccines against emerging infectious diseases (EID) and enable equitable access for all during outbreaks. Less than three years after its start, CEPI’s quick response during the COVID-19 pandemic propelled the development and manufacturing of new vaccines and it was the only entity with the mandate to invest in de-risking COVID-19 vaccine research and development (R&D) with global access in mind. CEPI’s role fills some of the critical gaps that governments do not address and on March 7-8, the U.K. Government will host the CEPI replenishment at the Pandemic Preparedness Summit. The replenishment aims to raise US$3.5 billion for the delivery of CEPI’s critical 2022-2026 strategy to accelerate the development of vaccines and other health tools against epidemic and pandemic threats.

Produced by Pandemic Action Network and DSW, CEPI’s Unique Impact Opportunity: Pandemic Preparedness & Response R&D examines the characteristics and ways in which CEPI is distinctly positioned to bolster global and regional health security initiatives, especially through vaccine R&D against EIDs, to ensure the world is equipped to end the COVID crisis for everyone and is better prepared for the next pandemic.

Key messages of the brief explainer include:

  • CEPI is uniquely positioned to address global pandemic threats through vaccine R&D for emerging infectious diseases.
  • Because of its commitment to equitable access for the global good, particularly in low- and middle-income countries, CEPI’s work leads to increased access and distribution of much-needed vaccines to traditionally underserved populations.
  • Building on its role, investments, and relationships, CEPI delivers catalytic impact globally in pandemic preparedness and response.
  • CEPI fills critical gaps in the vaccine R&D ecosystem that would otherwise go unfilled.
  • Emerging infectious diseases, such as COVID-19, do not recognize international borders. CEPI’s global mandate naturally complements regional and national R&D institutions that work to counter pandemic threats.

Read the full brief.

Amplify these messages using our social media toolkit.

 

Calling for Bold Pandemic Action at the EU-AU Summit

African and European civil society organizations (CSOs) call on leaders in advance of the African Union (AU) – European Union (EU) Summit on February 17-18, 2022, to show solidarity in ending not only the COVID-19 crisis but also responding to global epidemics including HIV, tuberculosis, and malaria and put in place mechanisms and resources to build resilience and prepare for future pandemics. It’s time for strong and sustained political will, collective alignment, and integrated end-to-end approaches. We call on leaders to adopt the following actions at the Summit:

  1. Tackle the crisis of inequitable access to COVID-19 vaccines, and support vaccination programs
  2. Address the crisis of inequitable access to COVID-19 tools, including tests, treatments, oxygen, and PPE
  3. Invest in and strengthen the research and development (R&D) capacity in Africa
  4. Support Africa’s mRNA Technology Transfer Hub and agree to waive intellectual property (IP) for COVID-19 vaccines and other medical tools
  5. Support health systems strengthening in African countries to enable prevention, detection and response to new and existing threats
  6. Reform and strengthen multilateralism

Humanity deserves a world where every country is equipped to end the COVID-19 crisis and every country is prepared to stop infectious disease outbreaks from becoming deadly and costly pandemics. 

Read the full letter

Pandemic R&D Agenda for Action: Fostering Innovation to End This Pandemic and Prepare for the Next One

As the world commences the third year of the COVID-19 pandemic, the case for investment in research and development (R&D) for medical countermeasures to prevent and combat emerging global health threats is stronger than ever. Despite tremendous scientific accomplishments in 2020-21, systemic gaps in pandemic-related R&D systems, supply chains, manufacturing, and delivery continue to stymie the roll-out of urgently needed technologies to all people who need them, everywhere, and are prolonging the pandemic.

COVID-19 and its variants have exposed longstanding market and systems failures and fragilities that pose barriers to timely and effective pandemic R&D. Not only do these persistent gaps threaten to undo progress achieved through the scientific breakthroughs, but they also exacerbate entrenched inequalities that leave the most vulnerable and disadvantaged people around the globe without access to lifesaving medical countermeasures and essential health services, and perpetuate gross power imbalances between high- and low-income nations. COVID-19 has also unleashed a multitude of actors in pandemic-related R&D across the innovation spectrum and across the globe, underscoring the growing need for more purposeful alignment, coordination, information-sharing, and transparency.

The world urgently needs a fit-for-purpose, proactive, and resilient pandemic R&D ecosystem. There is broad consensus that R&D is a vital component of building a world better equipped to prevent, prepare for, and respond to pandemic threats. Yet new investments in innovation will fail to meet their promise to save lives, prevent future global health emergencies, and build a healthier, safer world for all unless governments, international institutions, and industry are willing to heed the hard lessons of this pandemic and work together to fix these systemic failures and challenges.

Produced by Global Health Technologies Coalition and Pandemic Action Network with contributions by members of the Pandemic Action Network’s Pandemic Preparedness Working Group, this policy brief calls on world leaders to prioritize action in four key areas to close the critical R&D, manufacturing, and delivery gaps necessary to end the acute COVID-19 crisis and build a more resilient, equitable pandemic R&D ecosystem for the future.

Read the full brief here.

Partnering to Advance Health Security in the Middle East and Around the World

The global response to COVID-19 has shown that the world was ill-prepared to prevent and rapidly respond to a novel pandemic threat. Despite repeated warnings of the increasing threat of epidemics and pandemics, both public and private sector actors have failed to prioritize the forward-looking investments, systems, and structures that are necessary to ensure that life saving tools and medical countermeasures are ready to deploy to curb the spread of disease before it becomes a global health emergency.

When COVID-19 emerged in early 2020, the Kingdom of Saudi Arabia (KSA) determined that urgent and unprecedented action would be required. In response, the government mobilized emergency surge funding to kickstart research and development (R&D) of new medical countermeasures. As President of the G20 at the time, KSA in April 2020 partnered with the Coalition for Epidemic Preparedness Innovations (CEPI), investing US$150 million to help fuel the development of COVID-19 vaccines for global use. With this timely support, CEPI was able to leverage additional funding, expertise, and know-how from around the world to accelerate COVID-19 vaccine development with the aim of enabling rapid global, equitable, and affordable access to vaccines to save lives and slow the spread of the virus.

Although COVID-19 vaccines were developed in record time, most low- and middle-income countries have been left far behind their high-income country counterparts in terms of vaccine access. Without widespread global vaccination, the COVID-19 virus will continue to spread unchecked in many parts of the world, risking the emergence of new variants that can withstand existing vaccines and therapeutics while threatening to undo the progress that has been made. This underscores the urgent need to immediately ramp up the supply and delivery of COVID-19 vaccines to get more jabs in arms and reach the 70% global vaccination goal set at the Global COVID-19 Summit.

Produced by the Future Investment Initiative Institute and Pandemic Action Network, The Kingdom of Saudi Arabia: Partnering to Advance Health Security in the Middle East and Around the World calls for strategic investments in CEPI to be made by KSA and global partners to answer the call for increased, more predictable, longer-term, and sustainable funding for vaccine R&D, thus addressing variants and preparing the world for future pandemics.

Read the full report here.

Bridging the Innovation Gap to Prevent the Next Pandemic — Policy Brief

The world was woefully unprepared to prevent or rapidly respond to the COVID-19 pandemic. This is the result of decades of failure by national and global policymakers to address pandemics as a systemic and growing threat. A glaring weakness is that the ecosystem for pandemic preparedness research and development (R&D) — the system that is meant to develop vaccines, treatments, and other tools for known and unknown health threats — is rife with market and systems failures that prevent it from operating efficiently, effectively, and equitably.

While pandemics can affect the whole world and create large, global markets for vaccines, treatments, and other technologies, those markets have repeatedly failed to respond with the foresight and urgency needed to match the scale, scope, and unpredictability of pandemic threats. The world must urgently address the persistent market and systems failures in the global health R&D ecosystem to prepare for the next pandemic threat.

This policy brief, prepared by Pandemic Action Network, covers the market and systems failures in the pandemic preparedness R&D ecosystem and lays out the unique role that the Coalition for Epidemic Preparedness Innovations (CEPI) plays in leveraging partnerships and incentives to counter the failures as one key step in building a smarter, more effective and equitable pandemic R&D ecosystem.

Read the policy brief here and the full analysis here.

Pandemic Action Agenda: What World Leaders Should Do to Help Prevent the Next Pandemic

With global COVID-19 cases set to surpass 50 million and spiking across the United States and Europe, world leaders are gathering in a series of international summits to discuss what they will do to stop the pandemic. The current crisis demands urgent and united action as a global community, as no country will be safe from the virus until every country is safe.

But this pandemic didn’t have to happen, and the next one won’t wait. As they fight the current battle, leaders must also take steps NOW to bolster our global and national defenses against emerging pandemic threats before they materialize.

Synthesizing lessons of what has gone wrong in COVID-19 and in previous outbreaks and epidemics, the Pandemic Action Network’s Global Health Security Architecture Working Group has identified six priorities for international action to ensure the world is better prepared for the next pandemic. These are captured in our brief Pandemic Action Agenda paper released last month.

Pandemic Action Agenda Series

Now we’re pleased to release a series of Pandemic Action Agenda papers which expand on each of the six priority areas for action:

Pandemic Action Agenda Summary: Calling on world leaders to strengthen the global health security architecture and governance and make the world better prepared for pandemics.

Global Health R&D: Bolstering the global research and development architecture for health security.

Outbreak Detection: Enhancing the availability and use of reliable data and early warning systems to drive more effective preparedness and response to outbreaks.

Pandemic Financing: Mobilizing sufficient funding for national pandemic preparedness and global response efforts.

Country Capacity: Enhancing countries’ capacity to prevent and respond to outbreaks through technical assistance and improving health security infrastructure.

Pandemic Supplies: Solving supply chain bottlenecks and ramping up regional and local production and delivery to ensure health workers everywhere have access to sufficient quality personal protective equipment (PPE) and other frontline health supplies.

Metrics and Evaluation: Increasing accountability through more effective mechanisms to assess—and fill gaps in—country preparedness levels. COMING SOON

What You Can Do

Advocate for action. Help us deliver the Pandemic Action Agenda directly to key decision-makers in your country and international organizations, and press them to take action on these issues. Contact Naomi Komuro at [email protected] and let us know who you can reach (or we can give you ideas!).

Spread the word. Share the #PandemicActionAgenda on your social media channels and through other communications within your networks to help build us momentum to prioritize global preparedness. Find the social toolkit here.

Hold leaders to account. Sustained advocacy and communications are essential to avoid repeating the cycle of panic and neglect when it comes to deadly outbreaks. Follow up with decision-makers through emails, meetings or events, and ask them share what they are doing to respond to the Pandemic Action Agenda—and let us know what you learn to inform our ongoing advocacy efforts.

Every effort we make in the fight against COVID-19 should leave a longer-term legacy that better prepares humanity to more effectively deal with outbreaks and pandemics and—when possible—to prevent them at the source.

Want to learn more? Please contact Carolyn Reynolds, Co-Founder, Pandemic Action Network at [email protected]

Addressing Market Failures: The Role of CEPI in Bridging the Innovation Gap to Prevent the Next Pandemic

The global response to COVID-19 not only shows that the world was ill-prepared to prevent and respond to a pandemic caused by a novel respiratory pathogen, but also that there are an array of system and market failures in global health research and development (R&D). Solving for these failures ― and building a ready and sustainable R&D ecosystem for pandemic preparedness ― will be critical to advancing global health security and preventing future infectious disease outbreaks from becoming the next deadly and costly pandemic.

Addressing Market Failures: The Role of CEPI in Bridging the Innovation Gap to Prevent the Next Pandemic, produced by Volta Capital, Pandemic Action Network, and the Africa Centres for Disease Control and Prevention (ACDC), examines global health R&D failures to help inform policy and funding decisions to bolster preparedness and response for emerging pandemic threats. In particular, the paper considers the unique role of CEPI in addressing some of these failures, its strengths and challenges in the COVID-19 response, and the role it can play through its new strategy to bolster future epidemic and pandemic preparedness.

Key findings of the paper include:

  • Longstanding and persistent market and systems failures in global health R&D, especially for vaccines against novel pathogens, have left the world at grave risk of deadly and costly pandemics.
  • The world cannot wait for the next pandemic to bolster investments in R&D and preparedness for emerging infectious disease threats.
  • CEPI has a key role to play in a better prepared global R&D ecosystem.

To learn more, read the full analysis Addressing Market Failures: The Role of CEPI in Bridging the Innovation Gap to Prevent the Next Pandemic and the accompanying policy brief.

Share the key messages using our social media toolkit.

It’s Time to Pandemic-Proof the World: A 2021 Agenda for Action

The devastating health, economic, and social impacts of the COVID-19 global health crisis show that it is well past time for world leaders to prepare for pandemics as the existential, catastrophic, and growing global security threat they are. In 2010, well before COVID-19, there were six times more zoonotic spillover events than in 1980, and the number of new outbreaks continues to grow. Persistent gaps in international pandemic preparedness and response capacities have been flagged by various expert panels in the wake of previous health emergencies, but time and again, once the crisis disappears, political attention and funding shifts to other priorities. This dereliction of duty must stop once and for all.

Despite impacting people around the globe, COVID-19 has not affected everyone equally. The pandemic has exposed and exacerbated long-standing health and socio-economic inequalities within and across countries and in marginalized and vulnerable populations, including inequalities due to gender, race, ethnicity, class, and disability. The glaring disparities in global access to lifesaving COVID-19 vaccines, therapeutics, diagnostics, and vital tools such as oxygen and personal protective equipment (PPE) underscore the inequitable global health and preparedness system. And the lack of proactive attention by leaders to address and account for these inequities has significantly undermined the global COVID-19 response.

As the Global Preparedness Monitoring Board (GPMB) made clear in its September 2020 report A World in Disorder, the world cannot afford to continue to ignore or delay preparations to bolster our collective defenses against emerging pandemic threats. As they battle the current crisis, countries and international institutions must act now to ensure the world is better prepared for the next pandemic threat, which may be lurking just around the corner. These commitments should include building and reliably funding a well-trained and well-equipped health and research workforce, more resilient frontline health systems, timely and transparent disease surveillance, and effective supply chains for vaccines, diagnostics, PPE, and other tools to enable every country to detect, prevent, and rapidly respond to outbreaks before they become deadly and costly pandemics. It is time to invest in a smarter, more responsive, and more resilient global health security architecture.

Pandemic Action Network’s 100+ partners urge world leaders to take urgent action in the following areas to bolster the global COVID-19 response, hasten an end to this global crisis, and lay the groundwork for a more pandemic-proof world.

Support an equitable global response to COVID-19

The only way to end this pandemic is to end it for everyone through a coordinated global response. Yet as world leaders navigate the second year of responding to COVID-19 and securing vaccine doses for their constituents, nationalist inequitable approaches are still pervasive. Recent data shows that the world has now procured enough COVID-19 vaccine doses to reach herd immunity globally, but while some high-income countries have secured multiple times the number of doses as there are eligible adults in their countries, only 0.2% of doses administered have been in low- and middle-incomes countries (LMICs). Although it may seem intuitive for governments to first take action at home, this approach belies the fact that the virus — and its swiftly spreading variants — do not respect borders. Many countries that managed to control or even stop the spread of the virus earlier in the pandemic are once again seeing a surge in cases. There simply is no effective domestic response without also embracing a global approach. Everyone deserves to hope for a swift end to the pandemic, regardless of where they live. But it will only be possible if political leaders act globally as well as locally, knowing no country will be safe until every country is safe.

1. Accelerate global access and delivery of COVID-19 vaccines needed to achieve at least 70% coverage in all countries and enable an equitable global response and recovery.

World leaders should:

  • Fully fund the Access to COVID-19 Tools Accelerator (ACT-A) in 2021, filling the $22.1 billion funding gap as soon as possible with countries paying their fair share for this global public good. Countries should also commit to continue to invest in research and development (R&D) as well as scale-up of proven tools to prevent, test, and treat COVID-19 and ensure that medical countermeasures are effective against all strain mutations and all variants of concern. Given the scale of resources required, countries will need to tap into fiscal stimulus funding and other financial sources beyond official development assistance (ODA).
  • Agree to a roadmap to achieve at least 70% coverage of vaccines for LMICs, with at least 30% being secured, delivered, and administered in 2021. Leaders need to agree to a fully costed plan to achieve equitable global coverage as soon as possible. The full costs of delivering and administering doses in-country should be included in this roadmap, as well as the investments in vaccine education required to increase vaccine confidence.
  • Commit to donate, free of charge, all excess COVID-19 vaccine doses to the COVAX facility in parallel to their domestic vaccination efforts and start those donations as soon as possible. Countries should immediately announce commitments to share their full surplus supply on the most ambitious timeline possible, putting plans in place to deliver on this commitment as soon as is feasible in 2021 in line with COVAX’s dose sharing principles. These donations should not count as ODA, and should be in addition to funding the ACT-A.
  • Commit to “slot swaps” as another way to give COVAX additional supply. “Slot swaps” should be undertaken whereby high-income countries reallocate some of their existing orders immediately, potentially ordering replacement vaccines to arrive farther in the future, effectively giving their earlier “slots” to COVAX to help provide vaccines for LMICs to close the current acute gap in supply.
  • Ramp up global access and delivery of rapid testing, medical oxygen, and personal protective equipment to the frontlines. Continuing shortages of PPE and medical oxygen for frontline health workers and extremely limited deployment of testing — including genetic sequencing capacity to detect variants of interest — especially in LMICs, is hampering the global COVID-19 response and is a rate limiting factor for global rollout of COVID-19 vaccines and restoration of essential health services.

Prioritize and invest in pandemic preparedness and prevention

According to the IMF, the pandemic will cost the global economy and the World Bank projects that more than 160 million people will fall into poverty by the end of 2021. Conversely, recent estimates are that as little as $10-20 billion annually can ensure the world is much better prepared to detect, prevent, and respond to the next infectious disease outbreak before it becomes another deadly and costly pandemic. To minimize human lives lost from infectious diseases and lessen the impact on countries due to economic fallout, leaders should take the actions below to be prepared for the next pandemic.

2. Establish a catalytic, sustainable multilateral financing mechanism that is dedicated to promoting pandemic preparedness and prevention.

World leaders should:

  • Pledge new investments toward a target $20 billion initial capitalization co-funded from public, private, and philanthropic sources. Priorities for this new multilateral financing mechanism — which will fill a strategic gap in the existing global health architecture — should be on supporting LMICs to develop and implement national action plans for health security and pandemic preparedness, to close their urgent health security gaps, and foster a global “race to the top” among all nations for preparedness. The catalytic nature of this mechanism will help ensure both countries and other global health initiatives prioritize coordinated, multisectoral, prevention and preparedness funding in their domestic budgets, including support for country-level programmatic and managerial capacity in health systems strengthening.
  • Align funding with target country priorities to strengthen pandemic preparedness and containment as well as promote efforts toward pandemic prevention. Programs that should be financed at scale include detecting and stopping the spread of outbreaks and ensuring compliance with the International Health Regulations (IHRs), strengthening laboratory and manufacturing capacity, bolstering and protecting a trained, compensated health workforce, building and strengthening health information systems, ensuring resilient national and regional supply chains, One Health initiatives, and stopping zoonotic spillover from causing new outbreaks through measures such as reductions in deforestation and wildlife trade.

3. Bolster financing and at-the-ready global R&D capacity and coordination to combat emerging infectious diseases and pandemic threats without undermining important funding for existing epidemics research and innovation, including poverty-related and neglected diseases.

Applying the lessons learned from COVID-19, leaders should support the development and financing of mechanisms and initiatives that coordinate and catalyze research and development for new tools, including the Coalition for Epidemic Preparedness Innovations (CEPI), Global Antibiotic Research and Development Partnership, and other not-for-profit product development partnerships (PDPs) addressing the broad range of health threats.

World leaders should:

  • Fully fund CEPI’s $3.5 billion replenishment. This funding would support the organization’s moonshot initiative of compressing vaccine development for new pandemics to 100 days, and continuing efforts to develop vaccines for known threats. It would also support CEPI’s other objectives, including preparing clinical trial networks to quickly respond to new threats, coordinating with global regulators to streamline vaccine oversight, and linking manufacturing facilities to speed up global production.
  • Support integration of R&D into the Global Health Security Agenda (GHSA) framework to include R&D capacity-building for medical countermeasures. Inclusion of metrics through a GHSA R&D taskforce will help countries assess, prioritize, and better plan for strengthening their R&D capabilities.
  • Build on the ACT-A’s response to COVID-19 to ensure a robust, end-to-end, and sustainable investment in global health R&D for pandemic preparedness, including long-term investments to strengthen global research, laboratory, and manufacturing capacities. This future readiness state should also foster more investments and partnerships with diverse research and academic institutions to both build regional R&D prior to crises and scale up support during emergencies. Investments should be made with policies that promote equitable global access to and affordability of tools like vaccines, diagnostics, and therapeutics.

4. Strengthen global and national surveillance capacities & outbreak analytics.

COVID-19 has demonstrated global gaps in early detection and data sharing around emerging threats, as well as gaps in ongoing surveillance capacities of countries, especially low-resource countries. Current emerging infectious disease surveillance and investigation is poorly allocated, with the majority of the globe’s resources not focused on areas with the most zoonotic hotspots where the next emerging deadly pathogen is likely to originate.

World leaders should:

  • Strengthen integrated national disease surveillance capacities in LMICs. Such surveillance capacities should take a One Health approach and be responsive to local needs (i.e., give results in real-time for use by clinicians and public health officials). Such capacities should not be developed in a silo for pandemic risk monitoring; rather they should provide utility for day-to-day public health programs, leverage the latest developments in digital tools to streamline operations for health workers, and accelerate data flow and analysis.
  • Strengthen mechanisms and platforms that allow for independent sharing and verification of data related to emerging health threats, complementary to and in partnership with the WHO’s role in collecting data from official sources under the IHRs. Such capacities should enable and promote more transparency and accountability in data access for all relevant stakeholders.
  • Commit to the rapid publishing and sharing of line list and pathogen genome data into shared repositories (e.g., the Global Influenza Surveillance and Response System and the International Nucleotide Sequence Database Collaboration) to ensure that data necessary to monitor variants of concern can be acted upon before they become dominant.
  • Support innovations in outbreak detection and analytics capacity nationally through emergency operations centers, regionally through academic centers of excellence, and globally through laboratory and disease surveillance networks. The ACT-A has taught the community about the importance of collaboration and rapid response, and these lessons should be applied to future tools.

5. Bolster global capacities, institutions, and systems for pandemics, health security and resilient health systems, including through reforming WHO and strengthening international frameworks for pandemic preparedness and response.

World leaders should:

  • Build consensus for, and rapidly move to implement, proposals that will strengthen the WHO as the global coordinating authority on health. Leaders should support proposals for sustainable financing of the WHO, including incremental increases in assessed contributions and more (and more flexible) voluntary financing. Such resourcing should go hand-in-hand with strengthening the WHO’s normative and technical capacities, including the Chief Scientist’s Office, the Health Emergencies Programme, and the WHO Academy, and with encouraging greater staff mobility and budget flexibility to bolster the WHO’s capacities at the country-level. In line with the Framework for Engagement with Non-State Actors (FENSA), leaders must enable more robust and transparent engagement with key stakeholders such as civil society and the private sector.
  • Strengthen the IHRs to foster more timely and accountable response to pandemic threats, including to authorize international investigations. Leaders should afford the WHO the ability to independently investigate potential and emerging threats, specify better information sharing, and better calibrate the definitions of a Public Health Emergency of International Concern (PHEIC). Metrics on equity, R&D, infection prevention control, capacity strengthening, and water, sanitation and hygiene should also be included in the IHR Monitoring and Evaluation Framework, to incentivize countries to assess, plan, prioritize, and better support sustainable and resilient health systems, and promote healthcare worker safety.
  • Support other voluntary and compulsory instruments to strengthen accountability of nation states and foster multilateral cooperation for pandemic preparedness and response. Many gains can be made by strengthening existing mechanisms and instruments, which should be prioritized alongside the proposal for a new pandemic treaty. Such instruments should promote accountability in functions including ensuring novel countermeasures are treated as global public goods; motivating faster flow of financing to address direct and collateral impacts of pandemics, including protecting frontline health workers and social protection for vulnerable populations such as refugees and those living in conflict-affected areas; reaffirming the centrality of human rights considerations in the context of a pandemic; boosting domestic R&D and manufacturing capacity; and establishing up data surveillance systems, and norms and standards around data sharing and data privacy.
  • Scale up national and global vaccine education efforts to increase vaccine confidence, distribution, and uptake. Countries should have budgets dedicated for vaccine education within health ministries, initiate public education campaigns to manage the spread of misinformation online, and build capacity for vaccine hesitancy research. Training should be prioritized for frontline healthcare workers, community leaders, and others in how to engage in difficult conversations on vaccine hesitancy.

6. Promote equity-focused initiatives and human rights protections in all aspects of pandemic preparedness, response, and recovery, including specific attention to address the intersectional and gendered effects of outbreaks.

World leaders should:

  • Commit to equitable financing to support populations most at risk for morbidity and mortality, including addressing inequities due to disparities in gender, race/ethnicity, sexual orientation, socioeconomic status, and disability.
  • Ensure commitments to human rights and equity are met, in alignment with IHR Article 3 on human rights, the United Nations Security Council Resolution 1325 for Women, Peace and Security, the UN Political Declaration for Universal Health Coverage, and the UN Sustainable Development Goals.
  • Commit to equal and diverse representation on emergency committees, including the IHR Emergency Committee and UN technical working groups, with active and meaningful participation of gender advisors and civil society groups as non-participant observers of EC meetings.
  • Ensure that all data pertinent to pandemic preparedness and response collected by the WHO and other health-focused UN bodies (as well as national governments) is published and disaggregated by sex and key socioeconomic groups.

 


 

An array of upcoming international summits — including the G20, G7, World Health Assembly, World Bank/IMF Meetings, and UN General Assembly — offer opportunities for leaders to act on this agenda. Critically, while health ministers have a key role to play, a concerted effort to end pandemics is a whole of government effort — and must be addressed at the level of heads of state. That is why the Pandemic Action Network supports the GPMB’s call for the UN Secretary-General to convene a focused UN High-Level Summit on Pandemic Preparedness and Response to mobilize increased domestic and international financing and advance efforts toward a new international framework for pandemic preparedness. Such a summit at head of state level should take up the forthcoming findings of the Independent Panel for Pandemic Preparedness and Response (the Independent Panel), the G20 High-Level Independent Panel for Financing the Global Commons (HLIP), the International Health Regulations (IHR) Review Committee, and the proposal for a new international treaty on pandemic preparedness and response.

World leaders must seize this opportunity to commit to action and leave a legacy of a healthier and safer world. We can pandemic-proof the future if world leaders act now. The world can’t afford to wait.

Recommendations for the Biden-Harris Administration – Now or Never: An Agenda for Global Action to Make America and the World Safer from Pandemic Threats

We urge President-elect Biden and the incoming Biden-Harris Administration to launch and lead an aggressive agenda for action on global health security to end the COVID-19 pandemic as quickly as possible while accelerating global preparedness for the next pandemic. The following five-point agenda for action has been prepared by a group of leading U.S. global health policy experts, including two of our Pandemic Action Network co-founders. The outlined recommendations reflect the group’s collective experience as well as the conclusions of an extensive body of research and reports from numerous expert groups over the past five years. 

As the pandemic has upended lives and livelihoods in every household in America and every corner of the globe, the political moment is ripe for President-elect Biden to galvanize and lead a global coalition of public and private actors around a shared commitment to help prevent a deadly and costly pandemic like COVID-19 from happening again. President-elect Biden has the opportunity to leave a longer-term legacy that will better prepare humanity to more effectively address emerging pandemic threats, and break the persistent cycle of panic and neglect once and for all. Waiting until this crisis is over or until the next one happens will be too late. It’s now or never. 

Read the five-point agenda white paper here: Now or Never: An Agenda for Global Action to Make America and the World Safer from Pandemic Threats

Guaranteeing Equitable Access: Considerations During Vaccine Development Impacting Global Access

As world leaders come together to strategize how best to inoculate against, test for, and treat COVID-19 across the world, they must prioritize equity in their agendas to end this pandemic as swiftly as possible. The Pandemic Action Network’s Ending Barriers to Equitable Access Working Group has crafted a briefing with key considerations for decision-makers to ensure vaccines, therapeutics, and diagnostics reach those who need it most, when they need it most. We are all at risk until this disease is defeated internationally. We must ensure that low- and middle-income countries and vulnerable groups have equitable access to the tools needed to fight COVID-19 on every front. Read the full paper here.

Contributors to the paper include Deutsche Stiftung Weltbevölkerung (DSW), Global Citizen, Global Health Technologies Coalition (GHTC), PATH, and VillageReach. Special thank you to DSW for design support.

Break the Cycle of Panic and Neglect: Preventing the Next Pandemic

Time for unprecedented international cooperation say global health organizations

In the wake of the US decision to terminate the relationship with the World Health Organization (WHO), Pandemic Action Network and leading global health organizations have published a brief paper outlining some of the critical steps that the world needs to take to prevent pandemics.

The report sets out a key challenge for global leaders to work together in an unprecedented way to end COVID-19 as swiftly as possible and prepare for future pandemic threats.

The report, published jointly by the Pandemic Action Network, ONE, PATH, Nuclear Threat Initiative (NTI), Global Health Security Agenda Consortium (GHSAC), Management Sciences for Health (MSH) and Global Citizen highlights how years of ‘panic and neglect’ in the international health system has led to inadequate preparedness for pandemics in every country, resulting in the loss of hundreds of thousands of lives to COVID-19. Among the report’s recommendations is to strengthen WHO. Read the report HERE.